Author Archive for synbiochem

PhD Projects now available: BioDesign Engineering CDT

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Eleven fully funded projects are now available for 2020 start with the BioDesign Engineering CDT.

3 exciting projects will be hosted by the University of Manchester. 1) Genome scrambling and biosensor technologies for production of high value chemicals in synthetic yeast (Chem@Sc2.0). 2) Design, engineering, and analysis of viability, growth and bioproduction impact of synthetic ribosomal RNAs in yeast. 3) Biodesign and engineering of functionalised spider silk variants.

The 1+3 programme begins with a MRes at Imperial College London with the research project element hosted by your PhD institution. Find out more here

Dual award PhD in Synthetic and Systems Biology

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The University of Manchester and China’s Tsinghua University have come together to offer a unique dual degree PhD programme in Synthetic and Systems Biology, with successful applicants spending four life-changing years across Manchester and Beijing.
An opportunity to play a key role in developing sustainable, bio-economy solutions to address current and future global challenges – all while broadening your horizons with an incredible opportunity to study abroad.

Find out more here: https://www.synthetic-biology-dual-phd.manchester.ac.uk/

iGEM team make the news

Following the success of our previous iGEM teams it is great to be able to report a Gold Medal award for our 2019 team!

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This years’ team “Cutiful” modified E. coli bacteria to produce secretions that can colour, repair, straighten and fragrance hair.

In addition to their visit to the jamboree in Boston the team also hit the BBC news!

The team continued the success of Manchester’s iGEM teams – read more here

RRI team update

RRI Post Doctoral Researchers gain University Presidential Fellowships.

Dr Barbara Ribeiro

Dr Robert Meckin took up his fellowship in the School of Social Sciences in September to work on two research themes concerned with research methodology and technology.

The SYNBIOCHEM Centre welcomes 2 new members of the RRI team. Dr Andrew Watkins Chris Mellingwood to continue his work on automation in synthetic biology.

Future Biomanufacturing Research Hub

The University of Manchester has been awarded £10 million from UKRI (EPSRC/BBSRC) for a UK-wide biomanufacturing research hub that could pave the way for easier and quicker ways to make new medicines and sustainable energy solutions.
The Future BRH  led by Professor Nigel, based at the Manchester Institute of Biotechnology (MIB), will work in partnership with spokes at leading institutions and with industry to develop new Biotechnologies to speed up bio-based manufacturing in key sectors – pharmaceuticals, chemicals, engineering materials and biofuels. For more information see the website.

Metabolic Perceptrons for Neural Computing in Biological Systems

Tremendous progress has recently been made in machine learning including deep learning such that machine learning is now used in many tasks that affect our daily life and is currently making strives regarding our health. Yet, little has been done to interface machine learning with biological systems at the molecular level, this is noteworthy considering that deep learning methods are inspired by the neural network of our brain. Using artificial neural network for diagnosis has been undertaken for many diseases, however, biomarker concentrations are needed to both train the network and use it for diagnosis. Taking raw clinical samples as network input and producing an output that can directly be measured is required to construct the network in a biological system. A research team led by Prof. Faulon (SYNBIOCHEM center) has just taken a first step in this direction by engineering a simple neural network in an E. coli cell-free extract1. The network classifies samples having different metabolic compositions, is trained in silico and actuated in a cell extract through the modulation of enzyme concentrations. In a second study2, Faulon’s team partnered with J. Bonnet’s group at INSERM (France) and performed validation tests on human urine for metabolites detection. Read more

SYNBITECH2019

Building a multibillion-dollarsynthetic biology industry. Engineering the future with Synthetic Biology. Currently a multi-million dollar industry set to be come a multi-billion dollar industry. The leading synthetic biology conference of 2019 is taking place in London, UK. A diverse panel of speakers from across the world will share their opinions, insights and expertise

Register here: https://www.synbitech.com/

SHIKIFACTORY: A new EU partnership to deliver high-value compounds

The SYNBIOCHEM  Centre is part of an exciting new H2020 EU collaboration, ShikiFactory 100, worth 8 million Euros. This project gathers together 11 partners from 7 countries with the aim to produce over 100 high value compounds from the shikimate pathway, a hub of cell metabolism, through the development of an optimised chassis and implementation of novel biosynthetic routes for the production of known and new to nature molecules. Read more here

New biosynthetic pathway for the production of structurally unique antibiotic malonomycin

The Micklefield Lab’s latest paper has just been published in Nature Catalysis. The paper describes the discovery of a new biosynthetic pathway, with a highly unusual carboxylase enzyme (MloH), producing a structurally unique antibiotic malonomycin. The new findings might lead to the discovery of new antibiotics and may also provide new ways of making antibiotics which are urgently needed to combat emerging drug-resistant pathogens.

International Research Alliance for Antibiotic Discovery and Development Network

SYNBIOCHEM Co-director Eriko Takano is a founding participant in this new network which is one of eight networks awarded funding within the JPIAMR 2018 call for transnational networks “Building the Foundation of the JPIAMR Virtual Research Institute”. Each funded network will receive €50,000 to establish expertise clusters to identify research community needs and develop ideas to form the foundation for the JPIAMR Virtual Research Institute (JPIAMR-VRI). The IRAADD network includes internationally renowned groups with excellence in AMR research focussing on early stages of antibiotic discovery and development. This expert team will include natural products researchers, medical microbiologists, bioinformaticians, medicinal chemists and target-based drug designers, as well advisory partners from global alliances focussing on antibiotic development such as DNDi/GARDP and IMI-ENABLE. The network partners ill set up a cooperative platform to allow the sharing of scientific research data, translational knowledge and expert advice for the strategic development of new and advanced projects with the aim to take collaborative scientific research in the early stages of antibiotics discovery and development to a new level.

Find out more here