Independent Research Fellows: If you are an independent Research Fellow with your own funding or are currently applying for a research fellowship and would be interested in working with the Centre please contact Ros Le Feuvre (email@example.com)
PhD Studentships available for 2017:
NEW 2 BBSRC Case PhD studentship projects available to work with Dr Neil Dixon, Prof Rainer Breitling and Dr James Winterburn:
Engineering Mechano-Sensitive Channels for Biotechnology Application: Bacteria use a variety of secretion systems to translocate proteins across their cell membrane(s) these systems are involved in a range of essential cellular functions facilitating bacteria virulence, cell attachment, and nutrient scavenging . Secretion systems are extensively used in biotechnology for production of high-value recombinant products including therapeutic proteins and biocatalysts . Building on a recent discovery where we identified a novel protein translocation pathway that is regulated by a bacterial stress response pathway , this project will seek to both i) elucidate the underlying molecular mechanism associated with this phenomenon and ii) harness the novel translocation pathway for the production of valuable recombinant proteins. In collaboration with Dr Reddy’s EU Ltd based in Cambridge this project will provide training in cutting-edge biotechnology, namely synthetic biology enabled host engineering, stress response engineering, and bio-processing engineering important for future careers in both academic and industrial R&D. For more details see: Here
(BBSRC DTP CASE) Production of complex biologics: Host capacity analysis and capability engineering: This project will utilise next generation synthetic biology regulatory tools, to enhance the production and secretion of complex multimeric protein-based biologics from bacterial hosts. RNA-based regulatory tools (riboswitches) have been developed that control gene expression at the level of translation initiation [1-3]. To date we have used these tools to match our biotechnological demand to host cell synthetic capacity, for example matching expression rates to secretion capacity and inner membrane protein biogenesis allowing enhanced periplasmic secretion and production of recombinant inner membrane protein . This studentship project will seek to co-express and secrete commercially and clinically important multimeric protein-based biologics, such as F(abs), F(ab’)2, and T-cell receptors. In order to do this we will employ a combined synthetic biology design approach coupled with a systems analysis (transcriptomics) approach, to allow us to develop new capabilities and understand the underlying stress responses/capacity limitations. In collaboration with Cobra Biologics Ltd based in the UK this project will provide training in cutting-edge biotechnology, namely synthetic biology enabled host engineering, stress response engineering, and bio-processing engineering important for future careers in both academic and industrial R&D. For more details see: Here
Additional studentships for Sept 2017 may become available and will be advertised here asap. Please also check the Central University website for all applications for current PhD opportunities.
All job opportunities are also advertised on the main University of Manchester jobs website: https://www.jobs.manchester.ac.uk/