News and Events in brief

Our new posts can be found HERE

Discover our research in our new University of Manchester Chemistry videos on YouTube!
Demystifying the science behind our research papers, these videos provide a real world view of how important these discoveries are for day to day life. These include: Finding new routes to replacement molecules for oil using yeast; developing new routes to cheaper, better drugs by pairing man-made synthesis with natural enzymes; and harnessing the power of enzymes to make useful molecules for pharmaceuticals, polymers and plastics using alcohol. Find out more here

How robots could solve the antibiotics production Crisis: The World Health Organisation, has highlighted a lack of new antibiotics in development which is leading to a crisis in antibiotic production and our ability to tackle infections. However, cutting-edge technology gives us a chink of hope in what could otherwise be seen as an intractable problem says Eriko Takano, Professor of Synthetic Biology at The University of Manchester. SYNBIOCHEM is combining the strengths of biology with the power of engineering to find new ways to deal with this problem. Find out more here

Breakthrough in pharmaceuticals production with new enzyme discovery: Scientists have discovered a new enzyme that will make a drug used to treat Parkinson’s disease cheaper and quicker to produce. Researchers at the Universities of Manchester and York found the enzyme in Aspergillus oryzae, a kind of fungus used for making soy sauce. The discovery, ‘A reductive aminase from Aspergillus oryzae’ was published in Nature Chemistry.

New Publications: Full list and more detail can be found here: http://synbiochem.co.uk/publications/

Engaging the Senses, Understanding Publics: Research Methods, Science Engagement, and Synthetic Biology. Meckin R, Balmer A. Trends Biotechnol. 2017 Nov;35(11):1015-1017. Web link

Detection and Quantification of Butyrolactones from Streptomyces. Biarnes-Carrera M, Breitling R, Takano E. Methods Mol Biol. 2018;1673:117-128. doi: 10.1007/978-1-4939-7309-5_10. Web link

Computing exponentially faster: implementing a non-deterministic universal Turing machine using DNA Currin A, Korovin K, Ababi M, Roper K, Kell DB, Day PJ, King RD. J. Roy Soc Interface DOI: 10.1098/rsif.2016.0990 The paper which focuses on the creation of a new DNA-based computing device, can be viewed at: tinyurl.com/mtpcj8c

Tracking the emergence of synthetic biology Shapira, P., Kwon, S. & Youtie, J. Scientometrics (2017). doi:10.1007/s11192-017-2452-5.  Weblink

New funded collaborations

Using Synthetic Biology, Metagenomics, and Bioprocessing to provide alternative routes to high value chemicals a UK / Brazil collaboration. Lignin valorization in cellulosic ethanol plants: biocatalytic conversion via ferulic acid to high value chemicals. Summary: Lignin can be obtained as a by-product of cellulosic ethanol production, and is a potential source of renewable chemicals. Efficient valorisation of lignin is a major unsolved problem in the development of sustainable biorefineries. This 5 year project builds upon an existing BBSRC/FAPESP FAPPA partnership award, and brings together expertise in cellulosic ethanol production and in biocatalyst discovery (CTBE) with expertise in biocatalytic lignin valorisation (Warwick) and biocatalysis for high value chemicals production (Manchester,UCL).

Synthetic biology for high performance materials: In partnership with the Defence Science and Technology Laboratory (DSTL), University of Manchester (UoM) and the Synthetic Biology (SynBio) Research Centre SYNBIOCHEM, have launched a series of SynBio initiatives around the development of high performance materials with potential civilian and military applications. The research unites expertise in SynBio, additive manufacture, polymer science and allied disciplines and is focused on aramid fibres, multi-functional nanofibres, bioprocessing of agricultural waste and enzyme engineering for new materials. This work is complemented by additional projects funded through EPSRC/Innovate UK.

Development of thoroughly optimised production chassis for advanced pharmaceutical ingredients: A new H2020 funded project TOPCAPI, involving 8 academic and industry partners from 4 different countries (led by Prof. Takano) will exploit the natural fabrication power of actinomycetes as microbial cell factories to produce high-value pharmaceutical ingredients.

RoadMAPS to societal mobilisation for the advancement of responsible industrial technologies: Is a new EU programme that aims to connect industrial players with actors from research and civil society organisations to discuss and implement roadmaps for the responsible development of technologies in 3 key fields including SynBio (Led by Randles).

iGEM Team 2017:

Congratulations to our iGEM team: Manchester iGEM 2017 Awarded Gold at the Giant Jamboree! : This year our team of undergraduate students from the University of Manchester and Manchester Metropolitan University are working on a project that aims to engineer a bacterium that can take up and store increased levels of phosphate through micro-compartments. Read more

Conferences:

4-Day MBA “More Business Acumen” Building a SynBio-rich Biotech Business from Scratch. 19-23rd November 2017 Manchester, Run by SynBiCITE.

3rd UK SynBio meeting – 27-28th November 2017 Manchester – Web link