Latest Highlights

Members of SYNBIOCHEM have published a total of 455 publications in the last 5 years. Most have used infrastructure and resources available in the SYNBIOCHEM Centre. Recent highlights:

Dunstan MS, Robinson CJ, Jervis AJ, Yan C, Carbonell P,  Hollywood KA, Currin A, Swainston N, Le Feuvre R, Micklefield J, Faulon J-L, Breitling R, Turner N, Takano E,  Scrutton N. S. (2020). Engineering Escherichia coli towards de novo production of gatekeeper (2S)-flavanones: naringenin, pinocembrin, eriodictyol and homoeriodictyol. Synthetic Biology, In Press, DOI: 10.1093/synbio/ysaa012 Open Access

Carbonell P, Le Feuvre R, Takano E & Scrutton N. (2020) In silico design and automated learning to boost next-generation smart biomanufacturing. Synthetic Biology, Sep 28.

Robinson CJ, Carbonell P, Jervis AJ, Yan C, Hollywod KA, Dunstan MS, Currin A, Swainston N, Speiss R, Taylor S, Mulherin P, Parker S, Matthews NE, Malone KJ, Le Feuvre R, Shapira P, Barran P, Turner NJ, Micklefield J, Breitling R, Takano E, Scrutton NS. (2020). Rapid prototyping of microbial production strains for the biomanufacture of materials monomers. Metab. Eng.

Scrutton N, Malone K. (2020). Biomanufacturing; a path to sustainable economic recovery. New Statesman Biotechnology Special Edition. (

  1. Ahmed S, Leferink N, Scrutton N. (2019). Chemo-enzymatic Routes Towards the Synthesis of Bio-based Monomers and Polymers. Molecular Catalysis, 467: 95-110.
  2. Alvarez Gonzalez G, Dixon N. (2019). Genetically encoded biosensors for lignocellulose valorization. In: Biotechnology for Biofuels. 12: 246.
  3. Arora SK, Li Y, Youtie J, Shapira, P. (2019). Measuring dynamic capabilities in new ventures: Exploring strategic change in US green goods manufacturing using website data. J. Tech. Transfer.
  4. Auxillos JY, Garcia-Ruiz E, Jones S, Li T, Jiang S, Dai J, Cai Y. (2019). Multiplex genome engineering for optimizing bio-production in Saccharomyces cerevisiae. ACS Biochemistry581492-500.
  5. Bailey S, Payne K, Saaret A, Marshall S, Gostimskaya I, Kosov I, Fisher K, Hay S & Leys D. (2019). Enzymatic control of cycloadduct conformation ensures reversible 1,3 dipolar cycloaddition in a prFMN dependent decarboxylase. Nat. Chem. 11: 1049-57.
  6. Berepiki, A., Kent, R., Machado, L. F. M. & Dixon N. (2020). Development of high-performance whole cell biosensors aided by statistical modelling. ACS Synth. Biol. 9: 576-589.
  7. Beveridge R, Migas LG, Das RK, Pappu RV, Kriwacki RW, Barran PE. (2019). Ion Mobility Mass Spectrometry Uncovers the Impact of the Patterning of Oppositely Charged Residues on the Conformational Distributions of Intrinsically Disordered Proteins. J. Am. Chem. Soc. 141: 4908-18.
  8. Bornadel A, Bisagni S, Pushpanath A, Montgomery SL, Turner NJ, Dominguez B. (2019). Technical Considerations for Scale-Up of Imine-Reductase-Catalyzed Reductive Amination: A Case Study. Organic Proc. Res. and Dev. 23: 1262-68.
  9. Bozhüyük KA, Micklefield J, Wilkinson B. (2019). Engineering enzymatic assembly lines to produce new antibiotics. Curr. Opin. Microbiol. 51: 88-96.
  10. Burke A, Lovelock S, Frese A, Crawshaw R, Ortmayer M, Dunstan M, Levy C, Green AP. (2019). Design and evolution of an enzyme with a non-canonical organocatalytic mechanism. Nature. 570: 219-23.
  11. Carballo-Amador MA, McKenzie EA, Dickson AJ, Warwicker J. (2019). Surface patches on recombinant erythropoietin predict protein solubility: Engineering proteins to minimise aggregation. BMC Biotechnology 19: 26.
  12. Carbonell, P. (2019). Metabolic Pathway Design. A Practical Guide. Learning Materials in Biosciences. ISBN 978-3-030-29865-4 (Print).
  13. Carbonell P, Faulon JL, Breitling R. (2019). Efficient learning in metabolic pathway designs through optimal IFAC-PapersOnLine. 52: 7-12.
  14. Carbonell P, Radivojevic T, García Martín H. (2019). Opportunities at the Intersection of Synthetic Biology, Machine Learning, and Automation. ACS Synth Biol. 8: 1474-7.
  15. Castaño-Cerezo S, Fournié M, Urban P, Faulon JL, Truan G. (2020). Development of a Biosensor for Detection of Benzoic Acid Derivatives in Saccharomyces cerevisiae. Frontiers in Bioengineering and Biotechnology. 7: 372.
  16. Cojocariu C, Vinaixa M, Dunstan M, Jervis A, Silcock P, Rattray NJW. Understanding synthetic biology using the Q Exactive GC, Orbitrap GC-MS/MS and high-resolution accurate mass metabolomics library for untargeted metabolomics. ThermoFisher Application note.
  17. Cummings M, Peters AD, Whitehead GFS, Menon BRK, Micklefield J, Webb SJ, Takano E. (2019). Assembling a plug-and-play production line for combinatorial biosynthesis of aromatic polyketides in Escherichia coli. PLoS Biol. 18: e3000347.
  18. Currin A, Kwok J, Sadler JC, Bell E, Swainston N, Ababi M, Day P, Turner NJ, Kell DB. (2019). GeneORator: an effective strategy for navigating protein sequence space more efficiently through Boolean OR-type DNA libraries. ACS Synth Biol. 8: 1371-78.
  19. Currin A, Swainston N, Dunstan MS, Jervis AJ, Mulherin P, Robinson CJ, Taylor S, Carbonell P, Hollywood KA, Yan C, Takano E, Scrutton NS, Breitling R. (2019). Highly multiplexed, fast and accurate nanopore sequencing for verification of synthetic DNA constructs and sequence libraries. Synthetic Biology. 4: 1 ysz025, DOI: 10.1093/synbio/ysz025.
  20. Del Carratore F, Zych K, Cummings M, Takano E, Medema MH, Breitling R. (2019). Computational identification of co-evolving multi-gene modules in microbial biosynthetic gene clusters. Commun Biol. 2: 83.
  21. Del Carratore F, Schmidt K, Vinaixa M, Hollywood KA, Greenland-Bews C, Takano E, Rogers S, Breitling R. (2019). Integrated Probabilistic Annotation: A Bayesian-Based Annotation Method for Metabolomic Profiles Integrating Biochemical Connections, Isotope Patterns, and Adduct Relationships. Analytical chemistry. 91: 12799-807.
  22. Faber K, Fessner WD, Turner NJ. (2019). Biocatalysis: Ready to Master Increasing Complexity. Advanced Synthesis and Catalysis. 361: 2373-76.
  23. Gaffney CE, Dickson AJ, Elvin M. (2019). Metabolite profiling of mammalian cells in Cell Culture Engineering: Recombinant Protein Production. Advanced Biotechnology Series (eds Lee GM, Lee SY, Nielsen J, Stephanopolous G) 251-77.
  24. Garcia-Ruiz E, Auxillos J, Li T, Dai J, Cai Y. (2018). YeastFab: High-Throughput Genetic Parts Construction, Measurement, and Pathway Engineering in Yeast. Methods Enzymol. 608: 277-306.
  25. Grozinger L, Amos M, Gorochowski TE, Carbonell P, Oyarzún DA, Stoof R, Fellermann H, Zuliani P, Tas H, Goñi-Moreno A. (2019). Pathways to cellular supremacy in biocomputing. Nat Commun. 10: 5250.
  26. Hedison TM, Scrutton NS. (2019). Tripping the light fantastic in membrane redox biology: Linking dynamic structures to function in ER electron transfer chains. FEBS J. 286: 2004-17.
  27. Hedison T, Shenoy R, Iorgu AI, Heyes D, Fisher K, Wright G, Hay S, Eady RR, Antonyuk S, Hasnain SS, Scrutton NS. (2019). Unexpected roles of a tether harboring a tyrosine gatekeeper residue in modular nitrite reductase catalysis. ACS Catal. 9: 6087-99.
  28. Henderson F, Johnston HR, Badrock AP, Jones EA, Forster D, Nagaraju RT, Evangelou C, Kamarashev J, Green M, Fairclough M, Ramirez IB, He S, Snaar-Jagalska BE, Hollywood K, Dunn WB, Spaink HP, Smith MP, Lorigan P, Claude E, Williams KJ, McMahon AW, Hurlstone A. (2019). Enhanced Fatty Acid Scavenging and Glycerophospholipid Metabolism Accompany Melanocyte Neoplasia Progression in Zebrafish. Cancer Res. 79: 2136-51.
  29. Hillson et al, Le Feuvre R. Scrutton N. Freemont P. (2019). Building a global alliance of biofoundries. Nature Communciation, 9: 2040.
  30. Howell E, Scheufele D, Brossard D, Xenos M, Kwon S, Youtie J, Shapira P. (2020). Scientists’ and the Publics’ Views of Synthetic Biology. Synthetic Biology 2020: Frontiers in Risk Analysis and Governance. 371-87.
  31. Iorgu AI, Hedison T, Hay S, Scrutton N. (2019). Selectivity through discriminatory induced fit enables switching of NAD(P)H coenzyme specificity in Old Yellow Enzyme ene-reductases. FEBS J. 286: 3117-28.
  32. Iorgu AI, Cliff M, Waltho J, Scrutton N & Hay S. (2019). Isotopically labeled flavoenzymes and their uses in probing reaction mechanisms. Methods in Enzymology. 620: 145-66.
  33. Issa IS, Toogood HS, Johannissen LO, Raftery J, Scrutton NS, Gardiner JM. (2019). C3 and C6 Modification-Specific OYE Biotransformations of Synthetic Carvones and Sequential BVMO Chemoenzymatic Synthesis of Chiral Caprolactones. Chemistry. 25: 2983-8.
  34. Jeffreys LN, Poddar H, Golovanova M, Levy CW, Girvan HM, McLean KJ, Voice MW, Leys D, Munro (2019). Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs. Sci Rep. 9:1577.
  35. Jeffreys LN, Pacholarz KJ, Johannissen LO, Girvan HM, Barran PE, Voice MW, Munro AW. (2020). Characterization of the structure and interactions of P450 BM3 using hybrid mass spectrometry approaches.J Biol Chem. doi: 10.1074/jbc.RA119.011630.
  36. Jervis A, Carbonell P, Taylor S, Sung R, Dunstan M, Breitling, Takano E, Scrutton N. SelProm: a queryable and predictive expression vector selection tool for Escherichia coli. ACS SynBio8: 1478-83.
  37. Kempa EE, Hollywood KA, Smith CA, Barran PE. (2019). High throughput screening of complex biological samples with mass spectrometry – from bulk measurements to single cell analysis. The Analyst. 144: 872-91.
  38. Kearsey LJ, Prandi N, Karuppiah V, Yan C, Leys D, Toogood H, Takano E, Scrutton NS. (2019). Structure of the Cannabis sativa olivetol-producing enzyme reveals cyclization plasticity in type III polyketide synthases. FEBS J.  287: 1511-24.
  39. Kent R, Dixon N. (2019). Contemporary Tools for Regulating Gene Expression in Bacteria. Trends Biotechnol. 38: 316-33.
  40. Kent R, Dixon N. (2019). Systematic evaluation of genetic and environmental factors affecting performance of translational riboswitches. ACS Synthetic Biology. 8: 884-901.
  41. Koch M, Pandi A, Borkowski O, Batista AC, Faulon JL. (2019). Custom-made transcriptional biosensors for metabolic engineering. Curr Opin Biotechnol. 59: 78-84.
  42. Koch M, Duigou T, Faulon JL. (2020). Reinforcement Learning for Bioretrosynthesis. ACS Synth Biol. 19: 157-168.
  43. Kurgan G, Kurgan L, Schneider A, Onyeabor M, Rodriguez-Sanchez Y, Taylor E, Martinez R, Carbonell P, Shi X, Gu H, Wang X. (2019). Identification of major malate export systems in an engineered malate-producing Escherichia coli aided by substrate similarity search. Appl Microbiol Biotechnol. 103: 9001-11.
  44. Leferink NGH, Dunstan MS, Hollywood KA, Swainston N, Currin A, Jervis AJ, Takano E, Scrutton NS. (2019). An automated pipeline for the screening of diverse monoterpene synthase libraries. Sci Rep. 9: 11936.
  45. Leferink NGH,  Ranaghan KE,  Battye J, Johannissen LO,  Hay S,  van der Kamp M,  Mulholland AJ,   Scrutton NS. (2019). Taming the Reactivity of Monoterpene Synthases To Guide Regioselective Product Hydroxylation. Chem Bio Chem. 20: 1-7.
  46. Lin Y, Zou X, Zheng Y, Cai Y, Dai J (2019). Improving Chromosome Synthesis with a Semiquantitative Phenotypic Assay and Refined Assembly Strategy. ACS Synth Biol. 18: 2203-2211.
  47. Machado L, Currin A, Dixon N. (2019). Directed evolution of the PcaV allosteric transcription factor to generate a biosensor for aromatic aldehydes. J Biol Eng. 13: 91.
  48. Manning J, Tavanti M, Porter J, Kress N, De Visser S, Turner N, Flitsch S. (2019). Regio- and Enantio-selective Chemo-enzymatic C-H-lactonization of Decanoic Acid to (S)-δ-Decalactone. Ange. Chemie. 131: 5724-27.
  49. Marshall SA, Payne KAP, Fisher K, White MD, Ní Cheallaigh A, Balaikaite A, Rigby SEJ, Leys D. (2019). The UbiX flavin prenyltransferase reaction mechanism resembles class I terpene cyclase chemistry. Nat Commun. 10: 2357.
  50. Martella A, Firth M, Taylor B, Goeppert A, Cuomo E, Roth R, Dickson A, Fisher D. (2019). Systematic evaluation of CRISPRa and CRISPRi modalities enables development of a multiplexed, orthogonal gene activation and repression system. ACS Synthetic Biology 8: 1998-2006.
  51. Mattey A, Birmingham WR, Both P, Kress N, Huang K, Van Munster JM, Bulmer G, Parmeggiani F, Voglmeir J, Reyes Martinez JE, Turner NJ, Flitsch SL. (2019). Selective Oxidation of N-Glycolylneuraminic Acid Using an Engineered Galactose Oxidase Variant. ACS Catalysis. 9: 8208-12.
  52. Matthews S, Pacholarz K, France A, Jowitt T, Hay S, Barran P & Munro A. (2019). MhuD from Mycobacterium tuberculosis – probing a dual role in heme storage and degradation. ACS Infect. Dis. 5: 1855-66.
  53. Matthews N, Stamford L, Shapira P. (2019). Aligning sustainability assessment with responsible research and innovation: Towards a framework for Constructive Sustainability Assessment. Sustainable Production and Consumption. 20: 58-73.
  54. Meckin R. (2019). Changing Infrastructural Practices: Routine and Reproducibility in Automated Interdisciplinary Bioscience. Science, Technology, & Human Values,
  55. Matthews NE, Cizauskas CA, Layton DS, Stamford L, Shapira P. (2019). Collaborating constructively for sustainable biotechnology. Sci Rep. 9: 19033.
  56. Pandi A, Koch M, Voyvodic PL, Soudier P, Bonnet J, Kushwaha M, Faulon JL. (2019). Metabolic perceptrons for neural computing in biological systems. Nat Comm. 10: 3880.
  57. Pandi A, Grigoras I, Borkowski O, Faulon JL. (2019). Optimizing Cell-Free Biosensors to Monitor Enzymatic Production. ACS Synth Biol. 16: 1952-7.
  58. Ramsden JI, Heath RS, Derrington SR, Montgomery SL, Mangas-Sanchez J, Mulholland KR, Turner NJ. (2019). Biocatalytic N-Alkylation of Amines Using Either Primary Alcohols or Carboxylic Acids via Reductive Aminase Cascades. J. Am. Chem. Soc. 141: 1201-06.
  59. Randles S. (2019). Interview with Piero Bassetti, President of Fondazione Giannino Bassetti, in R. Schomberg & J. Hankins). International Handbook on Responsible Innovation: A Global Resource. Cheltenham: Edward Elgar. 522-528.
  60. Rajput S, McLean KJ, Poddar H, Selvam IR, Nagalingam G, Triccas JA, Levy CW, Munro AW, Hutton CA. (2019) Structure-Activity Relationships of cyclo(l-Tyrosyl-l-tyrosine) Derivatives Binding to Mycobacterium tuberculosis CYP121: Iodinated Analogues Promote Shift to High-Spin Adduct. J Med Chem. 62: 9792-9805.
  61. Ribeiro B, & Shapira P. (2019). Anticipating governance challenges in synthetic biology: Insights from biosynthetic menthol. Technological Forecasting and Social Change. 139: 311-320.
  62. Ribeiro B, & Shapira P. (2019). Private and public values of innovation: Asa patent analysis of synthetic biology. Research Policy. 49: 103875.
  63. Roberts A, Finnigan W, Wolde-Michael E, Kelly P, Blaker J, Hay S, Breitling R, Takano E, Scrutton N. (2019). Synthetic biology for fibres, adhesives and active camouflage materials in protection and aerospace. MRS Commun. 9: 486-504.
  64. Roberts A, Kelly P, Bain J, Morrison J, Wimpenny I, Barrow M, Woodward RT, Gresil M, Blanford CF, Hay S, Blaker J, Yeates S, Scrutton N. (2019). Graphene–aramid nanocomposite fibres via superacid co-processing. Chem. Commun. 55: 11703.
  65. Robinson CJ, Carbonell P, Jervis AJ, Yan C, Hollywod KA, Dunstan MS, Currin A, Swainston N, Speiss R, Taylor S, Mulherin P, Parker S, Matthews NE, Malone KJ, Le Feuvre R, Shapira P, Barran P, Turner NJ, Micklefield J, Breitling R, Takano E, Scrutton NS. (2020). Rapid prototyping of microbial production strains for the biomanufacture of materials monomers. Metab. Eng.
  66. Salvador M, Abdulmutalib U, Gonzalez J, Kim J, Smith AA, Faulon JL, Wei R, Zimmermann W, Jimenez JI. (2019). Microbial Genes for a Circular and Sustainable Bio-PET Economy. Genes. 10: 373.
  67. Shapira P. (2019). Religion and ideology in public and expert perceptions of Synthetic Biology: The role of values in understanding perceptions of societal risk and benefit of Synthetic Biology. Public Understanding of Science.
  68. Sinclair E, Bachman M, Addison D, Rohman M, Murray DC, Davies G, Mouchet E, Tonge ME, Stearns RG, Ghislain L, Datwani SS, Majlof L, Hall E, Jones GR, Hoyes E, Olechno J, Ellson RN, Barran PE, Pringle SD, Morris MR, Wingfield J. (2019). Acoustic Mist Ionization Platform for Direct and Contactless Ultrahigh-Throughput Mass Spectrometry Analysis of Liquid Samples. Anal Chem. 19: 3790-94.
  69. Sun C, Theodoropoulos C, Scrutton NS. (2019). Techno-economic assessment of microbial limonene production. Bioresource Technology. 300: 122666.
  70. Thompson MP, Derrington SR, Heath RS, Porter JL, Mangas-Sanchez J, Devine PN, Truppo MD, Turner NJ. (2019). A generic platform for the immobilisation of engineered biocatalysts. Tetrahedron. 75: 327-34.
  71. Torres M, Berrios J, Rigual Y, Latorre Y, Vergara M, Dickson AJ, Altamirano C. (2019). Metabolic flux analysis during galactose and lactate co-consumption reveals enhanced energy metabolism in continuous CHO cell cultures. Chem. Eng. Sci. 205: 201-211.
  72. Tramontina R, Galman J, Parmeggiani F, Derrington S, Timothy B, Turner N, Squina FM & Dixon N. (2019). Consolidated production of coniferol and other high-value aromatic alcohols directly from lignocellulosic biomass. Green Chemistry. 22: 144-52.
  73. Trivedi DK, Sinclair E, Xu Y, Sarkar D, Walton-Doyle C, Liscio C, Banks P, Milne J, Silverdale M, Kunath T, Goodacre R, Barran P. (2019).  Discovery of Volatile Biomarkers of Parkinson’s Disease from Sebum. ACS Central Science. 5: 599-606.
  74. Upton R, Migas L, Pacholarz K, Beniston R, Estdale S, Firth D, Barran P. (2019). Hybrid mass spectrometry methods reveal lot-to-lot differences and delineate the effects of glycosylation on the tertiary structure of Herceptin®. Chem. Sci. 10: 2811-20.
  75. Uyarra E, Ribeiro B, Dale-Clough L. (2019). Exploring the normative turn in regional innovation policy: responsibility and the quest for public value. European Planning Studies, 27: 2359-75.
  76. Voyvodic PL, Pandi A, Koch M, Conejero I, Valjent E, Courtet P, Renard E, Faulon JL, Bonnet J. (2019). Plug-and-play metabolic transducers expand the chemical detection space of cell-free biosensors. Nat Commun. 10: 1697.
  77. Wang Z, Porter A, Kwon S, Youtie J, Shapira P, Carley S & Liu X. (2019). Updating a Search Strategy to Track Emerging Nanotechnologies. J. Nanoparticle Res. 21: 199
  78. Welty R, Rau M, Pabit S, Dunstan MS, Conn GL, Pollack L, Hall KB. (2019). Ribosomal Protein L11 Selectively Stabilizes a Tertiary Structure of the GTPase Center rRNA Domain. J Mol Biol. 432: 991-1007.
  79. Zhang L, Stephens AJ, Lemonnier JF, Pirvu L, Vitorica-Yrezabal IJ, Robinson CJ, Leigh DA. (2019). Coordination Chemistry of a Molecular Pentafoil Knot. J. Am. Chem. Soc. 141: 3952-8.
  80. Zhang S, Sakuma M, Deora GS, Levy C, Klausing A, Breda C, Read KD, Ross BP, Wright Muelas M, Day P, O’Hagan S, Kell D, Schwarcz R, Leys D, Heyes D, Giorgini F, Scrutton N. (2019). A brain-permeable inhibitor of the neurodegenerative disease target kynurenine 3-monooxygenase prevents accumulation of neurotoxic metabolites. Commun Biol. 2: 271.
  81. Zhang S, Heyes DJ, Feng L, Sun W, Johannissen LO, Liu H, Levy CW, Li X, Yang J, Yu X, Lin M, Hardman SJO, Hoeven R, Sakuma M, Hay S, Leys D, Rao Z, Zhou A, Cheng Q, Scrutton NS. (2019). Structural basis for enzymatic photocatalysis in chlorophyll biosynthesis. Nature. 574: 722-25.
  1. Acevedo-Rocha C, Gamble C, Lonsdale R, Li A, Nett N, Hoebenreich S, Lingnau J, Wirtz C, Farès C, Hinrichs H, Deege A, Mulholland A, Nov Y, Leys D, McLean K, Munro A, Reetz M. (2018). P450-catalyzed regio- and diastereoselective steroid hydroxylation: Efficient directed evolution enabled by mutability landscaping. ACS Catal. 8: 3395-410.
  2. Ahmed WM, Geranios P, White IR, Lawal O, Nijsen TM, Bromley MJ, Goodacre R, Read ND, Fowler SJ. (2018). Development of an adaptable headspace sampling method for metabolic profiling of the fungal volatome. Analyst. 143: 4155-62.
  3. AlRabiah H, Allwood JW, Correa E, Xu Y, Goodacre R. (2018). pH plays a role in the mode of action of trimethoprim on Escherichia coli. PLoS One. 13(7):e0200272.
  4. Amara A, Takano E, Breitling R. (2018). Development and validation of an updated computational model of Streptomyces coelicolor primary and secondary metabolism. BMC Genomics. 9: 519.
  5. Archipowa N, Kutta RJ, Heyes DJ, Scrutton NS. (2018). Stepwise hydride transfer in a biological system: Insights into the reaction mechanism of the light-dependent protochlorophyllide oxidoreductase. Angew. Chem. Int. Ed. Engl. 57: 2682-6.
  6. Ascue Avalos G, Toogood H, Tait S, Messiha H, Scrutton N. (2018). From bugs to bioplastics: Total (+)-dihydrocarvide biosynthesis by engineered Escherichia coli. ChemBioChem: a European journal of chemical biology, ISSN (Print): 1439-4227.
  7. Baker K, Takano E, Breitling R. (2018). The “three c’s” of novel antibiotic discovery and production through synthetic biology: biosynthetic gene clusters, heterologous chassis, and synthetic microbial consortia. Advanced Biosystems,  54:114-20.
  8. Barley MH, Turner NJ, Goodacre R. (2018). Improved descriptors for the quantitative structure-activity relationship modeling of peptides and proteins. J. Chem. Inf. Model. 58: 234-43.
  9. Barran P, Baker E. (2018). Editorial overview: Omics. Curr. Opin. Chem. Biol. 42: A1-2.
  10. Bennett M, Thompson M, Micklefield J, Levy C, Menon B, Cronin V, Smith D, Herbert A, Dunstan M. Shepherd S. (2018). Structure and biocatalytic scope of coclaurine N-Methyltransferase. Angew. Chemie. 57: 10600-04.
  11. Biarnes-Carrera M, Breitling R, Takano E. (2018). Detection and quantification of butyrolactones from Streptomyces. Methods Mol. Biol. 1673: 117-28.
  12. Biarnes-Carrera M, Lee CK, Nihira T, Breitling R, Takano E. (2018). Orthogonal regulatory circuits for E. coli based on the γ-butyrolactone system of Streptomyces coelicolor. ACS Synth. Biol. 7: 1043-55.
  13. Birmingham WR. Turner NJ. (2018). A single enzyme oxidative “cascade” via a dual-functional galactose oxidase. ACS Catalysis. 8: 4025-32.
  14. Çakar MM, Mangas-Sanchez J, Birmingham WR, Turner NJ. Binay B. (2018). Discovery of a new metal and NAD+-dependent formate dehydrogenase from Clostridium ljungdahlii. Preparative Biochemistry and Biotechnology. 48: 327-34.
  15. Carbonell P, Jervis AJ, Robinson C, Yan C, Dunstan M, Swainston N, Vinaixa M, Hollywood KA, Currin A, Rattray NJW, Taylor S, Reynard Spiess R, Sung R, Williams AR, Fellows D, Stanford NJ, Mulherin P, Le Feuvre R, Barran P, Goodacre R, Turner NJ, Goble C, Chen GG, Kell DB, Micklefield J, Breitling R, Takano E, Faulon J-L, Scrutton NS. (2018). An automated Design-Build-Test-Learn pipeline for microbial production of fine chemicals. Communications Biology, 1: 66.
  16. Carbonell P, Koch M, Duigou T, Faulon JL. (2018). Enzyme discovery: enzyme selection and pathway design. Methods Enzymol. 608: 3-27.
  17. Carbonell P, Wong J, Swainston N, Takano E, Turner NJ, Scrutton NS, Kell DB, Breitling R, Faulon JL. (2018). Selenzyme: Enzyme selection tool for pathway design. Bioinformatics. 34(12):2153-4.
  18. Chapman MR, Cosgrove SC, Turner NJ, Kapur N, Blacker AJ. (2018). Highly productive oxidative biocatalysis in continuous flow by enhancing the aqueous equilibrium solubility of oxygen. Angew. Chemie, 57: 10535-9.
  19. Charles ED, Muhamadali H, Goodacre R, Pittman J. (2019). Biochemical signatures of acclimation by Chlamydomonas reinhardtii to different ionic stresses. Algal Research, In press.
  20. Cheallaigh AN, Mansell DJ, Toogood HS, Tait S, Lygidakis A, Scrutton NS, Gardiner JM. (2018). Chemoenzymatic synthesis of the intermediates in the peppermint monoterpenoid biosynthetic pathway. J. Nat. Prod. 81: 1546-52.
  21. Chisanga M, Muhamadali H, Ellis DI, Goodacre R. (2018). Surface-Enhanced Raman Scattering (SERS) in microbiology: illumination and enhancement of the microbial world. Appl. Spectrosc. 72: 987-1000.
  22. Choudry U, Heyes DJ, Hardman SJO, Sakuma M, Sazanovich IV, Woodhouse J, De La Mora E, Pedersen MN, Weik M, Schiro G, Scrutton NS. (2018). Photochemical mechanism of an atypical algal phytochrome. ChemBioChem. 19: 1036-43.
  23. Cosgrove SC, Hussain S, Turner NJ, Marsden SP. (2018). Synergistic chemo/biocatalytic synthesis of alkaloidal tetrahydroquinolines. ACS Catalysis, 8: 5570-3.
  24. Cosgrove SC, Brzezniak A, France SP, Ramsden JI, Mangas-Sanchez J, Montgomery SL, Heath RS, Turner NJ. (Jan 2018). Imine reductases, reductive aminases, and amine oxidases for the synthesis of chiral amines: discovery, characterization, and synthetic applications. Methods in Enzymology. 608: 131-49.
  25. Costa BZ, Galman JL, Slabu I, France SP, Marsaioli AJ. Turner NJ. (2018). Synthesis of 2,5-disubstituted pyrrolidine alkaloids via a one-pot cascade using transaminase and reductive aminase biocatalysts. ChemCatChem, In Press.
  26. Cummings M, Peters AD, Whitehead GFS, Menon BRK, Micklefield J, Webb SJ, Takano E. Assembling a plug-and-play production line for combinatorial biosynthesis of aromatic polyketides in Escherichia coli. Nature Communications, in revision Jan. 2018.
  27. Currin A, Dunstan MS, Johannissen LO, Hollywood KA, Vinaixa M, Jervis AJ, Swainston N, Rattray NJW, Gardiner JM, Kell DB, Takano E, Toogood HS, and Scrutton NS. (2018). Engineering the “missing link” in biosynthetic (−)-menthol production: bacterial isopulegone isomerase. ACS Catal., 8: 2012–20.
  28. Darbani B, Kell DB, Borodina I. (2018). Energetic evolution of cellular transportomes. BMC Genomics. 19, 1, 418
  29. de Mattos-Shipley KMJ, Greco C, Heard DM, Hough G, Mulholland NP, Vincent JL, Micklefield J, Simpson TJ, Willis CL, Cox RJ, Bailey AM. (2018). The cycloaspeptides: uncovering a new model for methylated nonribosomal peptide biosynthesis. Chem. Sci. 9: 4109-17.
  30. Delépine B, Duigou T, Carbonell P, Faulon JL. (2018). RetroPath2.0: A retrosynthesis workflow for metabolic engineers. Metabolic Engineering, 45: 158-70.
  31. Dhami N, Trivedi DK, Goodacre R, Mainwaring D, Humphreys DP. (2018). Mitochondrial aconitase is a key regulator of energy production for growth and protein expression in Chinese hamster ovary cells. Metabolomics, 14: 10.
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Blogs and Media

  1. Balmer A, Choosing an iGEM Project Weblink
  2. Balmer A. Public Perceptions, Knowledge Deficit and Expertise in Synthetic Biology. Weblink
  3. Gök A, Shapira P. “Tracking Synthetic Biology.” Blog post, Nesta. January 22, 2015. Weblink
  4. Li Y, and Shapira P. “Synthetic biology in China: An update from the field.” Blog – Rising Powers and Interdependent Futures, July 3, 2015. Weblink
  5. Shapira P. “Why synthetic biology has the potential to reshape our lives,” Blog, Policy@Manchester, October 28, 2015. Weblink
  6. Shapira P, and Gök A. “UK Synthetic Biology Centres tasked with addressing public concerns,” Science Political Science, The Guardian, January 30, 2015. Weblink

Engineering Escherichia coli towards de novo production of gatekeeper (2S)-flavanones: naringenin, pinocembrin, eriodictyol and homoeriodictyol (2020)

M. S. Dunstan, C. J. Robinson, A. J. Jervis, C. Yan, P. Carbonell, K. A. Hollywood, A. Currin, N. Swainston, R. Le Feuvre, J. Micklefield, J.-L. Faulon, R. Breitling, N. Turner, E. Takano, N. S. Scrutton

Synthetic Biology, In Press, DOI: 10.1093/synbio/ysaa012 Open Access