Pipeline
![SYNBIOCHEM - Pipeline](https://synbiochem.co.uk/wp-content/uploads/SYNBIOCHEM_icon_Pipeline.png)
SYNBIOCHEM PIPELINE
The SYNBIOCHEM Centre “Bio-Foundry” has established DESIGN, BUILD, TEST platforms supported by integrated DATA sharing and Responsible Research and Innovation (RRI), to transform fine and speciality chemicals production.
![SYNBIOCHEM - Pipeline SYNBIOCHEM - Pipeline](https://synbiochem.co.uk/wp-content/uploads/pipeline2.png)
DESIGN – BUILD – TEST – LEARN
The SYNBIOCHEM platforms have been integrated into a D/B/T/L pipeline to access new chemical space, generate new chemical diversity and high-level production through the:
- DESIGN of novel enzymes/pathways/chassis;
- BUILD of multiple pathways in host chassis using automated rapid assembly and…
- TEST/evaluation using advanced optimised ultra high-throughput (HTP) screening and analytical methods.
- LEARN methods then inform re-design and optimisation.
The SYNBIOCHEM pipeline is highlighted in the 2018 publication: Communications Biology.
The pipeline capabilities have now been further optimised for rapid prototyping of microbial production strains for the biomanufacture of diverse materials monomers with scale up to g/l (2020: Metab. Eng.).
![SYNBIOCHEM - Design Build Test Diagram SYNBIOCHEM - Design Build Test Diagram](https://synbiochem.co.uk/wp-content/uploads/SYNBIOCHEM_Design_Build_Test_Diagram.png)
FACILITIES
SYNBIOCHEM is extremely well equipped with high throughput robotics, mass spectrometry, picodroplet microfluidics, fermentation platforms and a wide range of design tools.