Scientists at The University of Manchester aim to develop new sustainable ways of manufacturing chemicals used in thousands of our everyday products. Professor Nigel Scrutton and his team at the MIB and SYNBIOCHEM are one of five beneficiaries of the BBSRC’s Strategic Longer and Larger Grants (sLoLaS) scheme which funds high-value long-term research projects.

The combined effect of fossil carbon depletion and climate change are forcing humankind to replace fossil fuels with cleaner more sustainable forms of energy as we tackle the demands of an ever increasing and ageing population, affordable healthcare provision, resource efficiency, food security and energy shortages. Fossil fuels currently provide the raw material for the manufacture of many everyday products that we take for granted including pharmaceuticals, food and drink, plastics and personal care.

This 5 year research programme is at the heart of this agenda developing bio-based SynBio technology to deliver bespoke SynBio solutions for chemicals/natural products synthesis that are smart, predictable and sustainable.

Professor Scrutton and his team will design bespoke biological parts and assemble them in novel ways to create a bio-based production pipeline within a synthetic, engineered microbial bio-factory. By adopting a production pipeline that embraces the ‘design-build-test-deploy’ life-cycle they will turn knowledge assets into innovative chemicals production solutions to support industrial and academic drug discovery programmes.

Professor Scrutton says the £3 million grant is a substantial boost for Manchester:
“Our vision is to harness the power of SynBio to propel chemicals/natural products production towards ‘green’ and sustainable manufacturing processes. More broadly, the programme will provide the general tools, technology platforms and SynBio ‘know-how’ that will impact widely in the sustainable manufacture of chemicals and natural products for development by the industrial sector.”

In total £15.8 million is being handed to five projects across the UK. These research projects were selected on scientific excellence and involve internationally leading research teams that require longer timescales, extensive resources and/or multidisciplinary approaches.

Greg Clark, Minister for Universities, Science and Cities, said:

“This funding will support world-leading research teams in Sheffield, Kent, Manchester, Glasgow and Oxford to address research gaps in bioscience for the benefit of the UK.

From harnessing the sun’s power for better biofuel production to investigating how to reduce costs for British sheep farmers, these research projects supported by almost £16m from government will help to find long-term solutions to some of our biggest challenges in areas like health, energy and agriculture.”

Professor Jackie Hunter, BBSRC Chief Executive, said:

“BBSRC’s sLoLaS scheme gives world-leading scientists based in the UK long-term funding to work on critical research challenges. In this round those challenges include producing clean energy, new ways to produce medicines and other valuable chemicals, and protecting livestock from disease.

Not only will these funded projects help the UK and the world to address these challenges, but it will build vital research capacity here in the UK and provide opportunities for economic and social benefits.”